Contraindications: Methyldrostanolone is contraindicated in individuals with existing hepatic impairment, elevated baseline liver enzymes, prostate pathology, or a history of androgen-sensitive conditions. Not for use in women due to the compound's high androgenic potency. Individuals under 21 years of age, or those with cardiovascular risk factors including hypertension, left ventricular hypertrophy, or dyslipidemia, should not use this product.
Side Effects: Hepatotoxicity is the primary dose- and duration-dependent risk, driven by 17α-alkylation — ALT and AST elevation is commonly reported even at 10–20 mg/day. Androgenic side effects including acne, accelerated scalp hair recession in genetically predisposed individuals, and increased sebum production reflect the compound's high AR affinity. HDL cholesterol suppression and LDL elevation are expected lipid-panel changes; cardiovascular monitoring is warranted throughout the cycle.
Monitoring: Blood panels including liver function tests (ALT, AST, bilirubin), full lipid panel, hematocrit, and blood pressure should be assessed at baseline, mid-cycle (week 2–3), and within two weeks of cycle completion. HPLC-confirmed tablet dosing (as supplied by Dragon Pharma) reduces concentration uncertainty but does not alter the biological monitoring requirement.
PCT: Post-cycle therapy with a SERM (tamoxifen 20–40 mg/day or clomiphene 50 mg/day) for a minimum of four weeks is required following any methyldrostanolone cycle. Liver support agents (TUDCA, NAC) should be continued through PCT to assist hepatic recovery. HPG axis suppression duration correlates with cycle length; longer cycles necessitate extended SERM protocols.