Contraindications: Methyldrostanolone tablets are contraindicated in individuals with pre-existing hepatic impairment, elevated baseline liver enzymes (ALT/AST above twice the upper reference limit), active cardiovascular disease, or diagnosed dyslipidaemia. Contraindicated in women of childbearing age and individuals under 21. Prostate-specific antigen (PSA) should be assessed in males over 40 before use.
Side_Effects: Oral 17α-alkylated androgens elevate hepatic transaminases; ALT and AST elevation is dose- and duration-dependent. HDL cholesterol suppression and LDL elevation occur with oral androgen use and represent a cardiovascular risk factor. Androgenic effects including acne, accelerated scalp hair thinning in genetically predisposed individuals, and increased sebaceous gland activity have been reported. Endogenous testosterone suppression is expected at effective doses.
Monitoring: Perform liver function tests (LFT panel including ALT, AST, ALP, bilirubin) at baseline, cycle midpoint, and two weeks post-cycle. Monitor a full lipid panel at the same intervals. Blood pressure should be self-measured weekly throughout the oral cycle. Haematocrit elevation (erythrocytosis) is possible; a CBC at cycle midpoint is advisable for cycles exceeding 4 weeks.
PCT: Because Methyldrostanolone suppresses the hypothalamic-pituitary-gonadal axis, post-cycle therapy with a SERM (Clomiphene or Tamoxifen) is required. The short biological half-life of oral Methyldrostanolone means residual plasma concentrations clear rapidly after the last tablet, allowing PCT to begin within 24 hours of cycle completion. Standard PCT duration is 4 weeks, with dose tapering in the second half.