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HGH Fragment 5mg/vial 1 Vial by Bio-Peptide
Lab Tested

HGH Fragment 5mg/vial 1 Vial by Bio-Peptide

5 (2 reviews)

HGH Fragment (176-191) is the synthetically produced C-terminal peptide spanning residues 176 to 191 of the human growth hormone sequence, supplied by Bio-Peptide as a lyophilised powder at 5 mg per vial, and designed to deliver selective lipolytic activity without engaging the anabolic or mitogenic pathways of full-length GH. Retaining only the fat-signalling region of the HGH molecule, this fragment promotes adipose tissue breakdown at a cellular level while leaving IGF-1 output and skeletal growth mechanisms entirely undisturbed. Each production batch is cleared through third-party HPLC sequence and purity analysis alongside LAL endotoxin screening before any vial is released for distribution.

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  • Stimulates targeted lipolysis via beta-3 adrenergic receptor activation on adipocytes
  • Produces no measurable rise in IGF-1, preserving natural growth axis integrity
  • Inhibits lipogenesis simultaneously — reducing new fat deposition while mobilising stored fat
  • Does not desensitise insulin receptors, keeping glucose metabolism stable throughout use
  • Lyophilised format extends shelf life and protects peptide sequence fidelity during storage
  • Batch-level HPLC purity and LAL endotoxin certification confirm research-grade quality
  • Narrow molecular target means a cleaner side-effect profile compared to full-spectrum GH peptides

Key takeaways

  • Target adipose tissue selectively using the isolated 176-191 HGH sequence.
  • Expect zero IGF-1 elevation — the GH receptor pathway stays inactive.
  • Inject subcutaneously in a fasted state for peak lipolytic response.
  • Reconstitute with bacteriostatic water and refrigerate; use within 28 days.
  • Verify every batch: HPLC purity and LAL endotoxin certificates included.

A Precision Lipolytic Agent Derived from the HGH Sequence

HGH Fragment (176-191) is defined as the synthetically produced peptide corresponding to residues 176 through 191 of the native human growth hormone chain — a segment that carries the full fat-mobilising capacity of HGH while being structurally incapable of binding the primary GH receptor responsible for growth and IGF-1 stimulation. Research published in peer-reviewed endocrinology literature confirms that this terminal sequence regulates lipolysis independently of the hypothalamic-pituitary-IGF axis. Compared to full-length HGH, Fragment 176-191 produces equivalent or superior adipocyte mobilisation with none of the insulin-desensitising side effects associated with supraphysiological GH levels.

How the Fragment Drives Fat Loss Without Growth Effects

Fragment 176-191 activates beta-3 adrenergic receptors on adipocytes, stimulating cyclic AMP-mediated lipolysis — the same enzymatic cascade triggered by catecholamines during fasting. The peptide inhibits lipogenesis in fat cells, meaning it simultaneously reduces new fat storage while accelerating release of stored fatty acids into circulation for oxidation. Crucially, the fragment does not interact with the GH receptor's binding site responsible for IGF-1 upregulation, which is why serum IGF-1 concentrations remain unchanged during administration — a key distinction documented in rodent and in-vitro assay data. This selective receptor profile makes the compound uniquely suited to fat-loss phases where preserving insulin sensitivity is a priority.

Dosing Context and Timing

Research protocols typically administer Fragment 176-191 at 250–500 mcg per injection, subcutaneously, in a fasted state — most commonly upon waking or 30 minutes before training — to exploit the elevated lipolytic milieu created by low circulating insulin. Cycle durations observed in research contexts range from 8 to 12 weeks. Because the fragment carries no androgenic, oestrogenic, or growth-promoting properties, post-cycle endocrine recovery is not a concern in the same framework as anabolic steroids.

Quality Verification

Bio-Peptide's HGH Fragment (176-191) undergoes third-party HPLC sequence and purity analysis alongside LAL (Limulus Amebocyte Lysate) endotoxin testing on every production batch; certificates are batch-specific and traceable. Lyophilisation preserves peptide integrity during storage, with each vial sealed under inert atmosphere to prevent oxidative degradation.

Usage

  1. Allow the sealed vial to reach room temperature before handling to minimise thermal shock to the lyophilised peptide.
  2. Using an insulin syringe, draw 1–2 ml of bacteriostatic water and inject it slowly down the inner wall of the vial — never directly onto the powder cake.
  3. Swirl the vial gently in a circular motion until fully dissolved; do not vortex or shake, as mechanical agitation degrades peptide bonds.
  4. Calculate your dose volume: if 1 ml of bacteriostatic water was added to 5 mg, each 0.05 ml (50 µl) equals 250 mcg.
  5. Inject subcutaneously into the abdominal region or another low-fat subcutaneous site using a 29–31 gauge insulin syringe, in a fasted metabolic state to maximise lipolytic synergy.
  6. Store the reconstituted vial upright at 2–8 °C; label with the date of reconstitution and discard after 28 days or if any cloudiness or particulate matter appears.

Warnings

Contraindications: Not intended for use in individuals with active neoplastic disease, pregnancy, or lactation. Persons with a history of hypersensitivity to synthetic peptides should not administer this compound. This product is supplied for research purposes only and is not approved by the FDA or EMA for human therapeutic use.

Side Effects: Reported observations in research settings include transient injection-site redness or minor oedema, mild water retention at higher doses, and occasional fatigue on first administration. Unlike full-length GH peptides, carpal tunnel symptoms and joint pain are not associated with Fragment 176-191 due to the absence of IGF-1 stimulation.

Monitoring: Periodic fasting glucose and insulin measurements are advisable during extended protocols to confirm the absence of metabolic disruption. Track body composition changes at four-week intervals using DEXA or caliper measurements to validate fat-loss outcomes.

PCT: No post-cycle therapy is required following Fragment 176-191 use. The compound does not suppress endogenous GH secretion, LH, FSH, or testosterone; therefore, no selective oestrogen receptor modulator (SERM) or gonadotropin protocol is indicated upon discontinuation.

Frequently asked questions

Why does HGH Fragment 176-191 only target fat and not cause growth effects?
Fragment 176-191 lacks the N-terminal binding domain of full HGH that engages the GH receptor and triggers IGF-1 production. Without that receptor interaction, no anabolic or growth-promoting cascade is activated. The retained C-terminal sequence binds preferentially to fat-cell receptors governing lipolysis, confining biological activity strictly to adipose tissue mobilisation.
Does IGF-1 rise when using HGH Fragment 176-191?
No — serum IGF-1 remains unaffected during Fragment 176-191 administration. Because the peptide cannot bind the primary GH receptor site that signals the liver to produce IGF-1, the hepatic IGF-1 secretion pathway is never activated. This is one of the most clinically relevant distinctions between the fragment and full-length growth hormone therapy.
When is the optimal time to inject HGH Fragment 176-191 for maximum fat-burning effect?
Research protocols favour administration in a fasted state — typically first thing in the morning or 30 minutes before a training session — when circulating insulin is at its lowest. Low insulin levels remove the primary inhibitor of lipolysis, allowing Fragment 176-191 to engage adipocyte beta-3 adrenergic receptors with minimal interference and maximise free fatty acid release into circulation.
How do you reconstitute and store HGH Fragment 176-191 5mg after opening?
Add 1–2 ml of bacteriostatic water slowly down the side of the vial — never shake; swirl gently until the lyophilised powder dissolves completely. Once reconstituted, refrigerate at 2–8 °C and use within 28 days. Draw doses with an insulin syringe (29–31 gauge) for subcutaneous injection. Discard any vial showing particulate matter or discolouration.
Is post-cycle therapy required after a HGH Fragment 176-191 research cycle?
No standard PCT protocol is required. Fragment 176-191 exerts no androgenic, oestrogenic, or pituitary-suppressive activity; it does not engage the hypothalamic-pituitary-gonadal axis. Endogenous GH pulsatility and sex hormone levels are unaffected, so the hormonal recovery framework applied to anabolic steroids or SARM cycles is not applicable to this peptide. (2) angle_used

Manufacturer

Bio-Peptide's standing in the European research peptide sector is built on a principle its founders embedded into commercial operations from day one: the right to market a compound was conditional on an independent laboratory — not an internal QC team — certifying both the peptide's sequence identity and its endotoxin safety before a single vial shipped. That two-step external verification framework — HPLC confirmation of molecular sequence and purity percentage, paired with LAL (Limulus Amebocyte Lysate) endotoxin screening — has never been treated as an optional enhancement; it is a non-negotiable production gate applied to every batch, including HGH Fragment (176-191). Manufacturing infrastructure operates in alignment with cGMP standards, ensuring that documentation, environmental controls, and raw-material sourcing meet the same benchmarks applied to pharmaceutical-adjacent production environments. The result is a traceable chain from amino-acid procurement through lyophilisation and final vial release — each step auditable, each certificate linked to a specific batch identifier.

Product details

BrandBio-Peptide
Active ingredienthgh fragment 176-191
Also known asHGH Fragment, Frag 176-191, AOD-Fragment, HGH Fragment (176-191), Bio-Peptide HGH Fragment
Strength5 mg
FormVial
Pack size1 piece
Item numberPEPT-HGHF-BIO-001

Reviews

5/5

2 reviews

  • Rating: 5 out of 5 starsPete33Verified purchase

    leaning out nicely

    250mcg twice daily fasted morning before cardio and again before bed. 10 wks in and dropped from 96kg to 91.5kg while actually gaining a bit of shoulder and arm size. Waist is noticeably tighter. No blood sugar issues, no hunger, no shutdown. Exactly what fragment is supposed to do. Vials arrived well packaged, cold pack in the box was a nice touch. Chuffed with this

  • Rating: 5 out of 5 starsLloydVerified purchase

    Fragment actually works

    Been sceptical of peptides for years but gave this a proper run 500mcg per day split into two shots, 12 weeks. Lost 4.2kg, bloods showed no change in glucose or lipids which I was watching. Stubborn lower belly fat is actually responding. Clean powder, dissolved quickly with bac water, no PIP at all. Reordering the 10mg next.

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