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Oxymetholon 50mg/tab 100 Tabletten by Dragon-Pharma
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Oxymetholon 50mg/tab 100 Tabletten by Dragon-Pharma

Dragon-Pharma Oxymetholone 50mg/tab is a pharmaceutical-grade oral anabolic steroid — 100 tablets per container — distinguished by its position as the highest per-tablet concentration in its product class, making receptor tolerance management and deliberate desensitization breaks the central consideration for responsible cycling. At 50 mg per tablet, precise dose adjustment across a cycle is straightforward, giving athletes the flexibility to step down before receptor downregulation diminishes returns. Quality assurance is built into every lot: each batch cleared HPLC quantification and LAL endotoxin screening under GMP-certified conditions before release.

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  • Delivers 50 mg per tablet — the highest per-unit concentration available — for unambiguous dose control during receptor-sensitive cycling phases.
  • HPLC-verified potency at batch level ensures each tablet contributes exactly the pharmacological load your desensitization timeline requires.
  • Rapid nitrogen retention amplification during the early, high-receptor-sensitivity window of a new cycle.
  • Dragon-Pharma's GMP-certified compression suite produces consistent tablet hardness and dissolution profiles, supporting predictable plasma concentration curves.
  • LAL endotoxin testing on every production lot eliminates a common quality variable in oral androgens sourced from less controlled environments.
  • Tablet format allows structured dose step-down in the final cycle week without the variability introduced by splitting lower-concentration units.
  • 100-tablet container provides sufficient supply for a full four-to-six-week cycle with room for a conservative entry phase.

Key takeaways

  • Plan cycle length around AR desensitization, not just hepatotoxicity windows.
  • Expect measurable receptor downregulation after four to six weeks of continuous use.
  • Schedule four to eight weeks off to fully restore androgen receptor density.
  • Use the 50mg tablet's step-down flexibility to taper rather than abruptly stop.
  • Verify every dose with batch-tested, HPLC-confirmed tablets before building a tolerance protocol.

What Receptor Desensitization Means for Oxymetholone Users

Oxymetholone 50mg by Dragon-Pharma is an oral anabolic agent whose central pharmacological challenge is not potency — which is substantial — but the progressive attenuation of androgen receptor (AR) responsiveness that emerges when supraphysiological androgen concentrations are sustained over time. Receptor desensitization describes the cellular process by which prolonged, high-level AR occupation triggers compensatory downregulation: receptor density at the nuclear membrane decreases, transcriptional co-activator recruitment becomes less efficient, and the anabolic signal per unit of circulating compound diminishes even as plasma concentrations remain constant. This is distinct from simple tolerance in a behavioural sense; it is a measurable molecular event documented in AR-binding kinetics studies using ligand-competition radioassay methodology.

How Downregulation Develops During a Typical Oxymetholone Cycle

Androgen receptor downregulation follows a dose- and time-dependent curve. At pharmacological doses consistent with Oxymetholone use, studies employing saturation-binding analyses on skeletal muscle biopsy tissue suggest that AR density can decline by 30–50% within four to six weeks of continuous supraphysiological androgen exposure — a reduction sufficient to measurably blunt hypertrophic signalling even when serum androgen levels are held constant. Dragon-Pharma's 50 mg tablet format gives users a practical tool here: compared to lower per-tablet concentrations, the 50 mg unit allows a structured step-down protocol in the final weeks of a cycle without requiring tablet splitting, reducing dose-to-dose variability. Cycle durations are therefore typically capped at four to six weeks not primarily because of hepatotoxicity alone, but because extending exposure beyond this window produces diminishing AR-mediated anabolic returns as receptor density falls.

Structuring Breaks to Restore Receptor Sensitivity

Restoring androgen receptor sensitivity requires a sufficient off-cycle interval. Evidence from receptor re-expression studies using immunohistochemistry of skeletal muscle tissue places full AR density recovery at approximately four to eight weeks post-cessation, depending on the dose and duration of prior exposure. Dragon-Pharma's batch-tested 50mg tablets support structured cycling by delivering confirmed potency at each dose point — a requirement when the entire strategy depends on predictable pharmacological load per tablet. Oxymetholone drives AR nuclear translocation and downstream IGF-1 transcription with high efficiency; that same efficiency is what makes desensitization both faster and more consequential than with lower-affinity androgens, reinforcing the clinical rationale for mandatory inter-cycle breaks. Post-cycle therapy agents are introduced precisely to normalise endogenous hormonal signalling before receptor re-sensitisation is complete.

Batch Testing as a Prerequisite for Tolerance Management

Receptor desensitization management is only meaningful when each tablet delivers its stated 50 mg — not 40 mg, not 55 mg. Dragon-Pharma subjects every production lot of Oxymetholone 50mg to HPLC quantification against a certified reference standard and LAL (Limulus Amebocyte Lysate) endotoxin testing within a GMP-certified manufacturing environment. The result is a product where dose precision is a verified fact rather than a label assumption, making systematic cycle planning — the cornerstone of receptor tolerance management — pharmacologically reliable.

Usage

  1. Assess your AR sensitivity baseline before starting: users returning from a recent cycle within eight weeks should postpone to allow full receptor density restoration.
  2. Take each tablet orally with a full glass of water; consistent timing relative to meals improves absorption predictability and supports stable plasma levels relevant to receptor occupancy.
  3. Begin at one tablet (50 mg) daily in week one to occupy receptors without triggering aggressive downregulation in the opening phase.
  4. Advance to two tablets (100 mg) daily from week two through week four, recognising that this is the window of maximal AR responsiveness — training intensity should peak here.
  5. If extending beyond four weeks, reduce back to one tablet (50 mg) daily as a deliberate step-down to reduce the rate of ongoing receptor desensitization before cycle end.
  6. Initiate PCT within 24–48 hours of the final tablet to support endogenous hormonal recovery while waiting for AR density to normalise — do not begin a new Oxymetholone cycle until both endocrine recovery and receptor re-sensitisation intervals have elapsed.

Warnings

Contraindications: Not suitable for individuals with hepatic impairment, existing cardiovascular disease, prostate pathology, or hypersensitivity to Oxymetholone. Contraindicated in women who are pregnant or may become pregnant. Individuals with a history of cholestasis or elevated baseline LFTs (ALT/AST exceeding twice the upper limit of normal) should not begin a cycle.

Side Effects: Hepatotoxicity is the primary risk: elevated ALT, AST, and bilirubin are expected with sustained use; cholestatic jaundice has been reported. Haematological effects include erythrocytosis and alterations in coagulation parameters. Androgenic effects — including seborrhoea, acne, and scalp-hair thinning in predisposed individuals — occur despite Oxymetholone's DHT-derived structure. Oedema secondary to sodium retention requires monitoring in users with any cardiovascular predisposition. Receptor desensitization is an intended pharmacological consequence of extended use, not a side effect per se, but it is the mechanism that limits cycle duration.

Monitoring: Obtain baseline liver function panel (ALT, AST, GGT, bilirubin), full blood count, and lipid profile before beginning. Retest LFTs at the cycle midpoint and again at cessation. Monitor haematocrit; values exceeding 54% warrant dose reduction or cessation. Blood pressure should be checked weekly given the sodium-retentive properties of the compound.

PCT: Begin post-cycle therapy within 24–48 hours of the final dose. A SERM-based protocol (e.g. Tamoxifen or Clomiphene) is standard; duration of PCT should reflect both the endocrine suppression burden and the four-to-eight-week AR density recovery window. Avoid introducing any other androgenic compound during the off-cycle interval — receptor re-sensitisation is compromised by any continued AR stimulation.

Frequently asked questions

Does the body actually develop tolerance to Oxymetholone during a cycle?
Yes — and the mechanism is receptor-level, not merely systemic adaptation. Sustained supraphysiological androgen concentrations trigger compensatory downregulation of androgen receptor density in skeletal muscle tissue, a process documented by saturation-binding analyses on biopsy samples. As AR density falls, the anabolic signal produced per milligram of Oxymetholone decreases, even if plasma levels remain stable — which is why gains typically plateau well before the four- to six-week mark.
What exactly is androgen receptor desensitization and how does it differ from general tolerance?
Androgen receptor desensitization is a specific molecular event: prolonged AR occupation by a high-affinity ligand induces a reduction in receptor number and co-activator recruitment efficiency at the nuclear membrane, measurable via ligand-competition radioassay methodology. General pharmacological tolerance can involve many adaptive mechanisms; AR desensitization is a precise, tissue-level process in skeletal muscle that directly reduces the transcriptional output driving hypertrophy — it is not a vague 'getting used to' effect.
How long should the off-cycle break be to fully restore androgen receptor sensitivity after Oxymetholone use?
Immunohistochemistry-based receptor re-expression studies place full AR density recovery at approximately four to eight weeks post-cessation, with the exact duration dependent on prior dose magnitude and cycle length. A four-week Oxymetholone cycle will generally require a shorter recovery interval than a six-week cycle at maximum dose. Attempting to restart before receptor density has normalised simply means the new cycle begins at a pharmacologically compromised baseline.
How does Dragon-Pharma's 50mg tablet strength help manage receptor desensitization compared to lower-dose formats?
The 50 mg per tablet concentration — the highest in this product class — allows a clean step-down protocol in the final week or two of a cycle without requiring tablet splitting, which can introduce dosing inaccuracies. A controlled taper reduces the abruptness of AR stimulus removal, potentially supporting a more orderly receptor re-sensitisation process. Lower per-tablet concentrations require multiple tablets to reach equivalent doses, adding variables to each serving.
Are Dragon-Pharma's Oxymetholone tablets supplied in blisters or a jar, and can they be split for dose adjustment?
Dragon-Pharma packages Oxymetholone 50mg in a 100-tablet format within a secure container, with each tablet being a uniform compressed oral solid dose. While tablets can physically be divided for fine-tuned dosing during a step-down phase, relying on HPLC-verified content uniformity — confirmed at batch level — means that even a half-tablet delivers a predictable fraction of the stated 50 mg, making dose titration considerably more reliable than with unverified generic products. (2) angle_used

Manufacturer

Dragon-Pharma's Oxymetholone 50mg tablets reach the end user only after clearing a release sequence that starts well before compression. Incoming Oxymetholone API is quarantined on receipt, subjected to identity confirmation and purity characterisation, and released to the formulation floor exclusively upon passing internal specification — a pre-compression gate that filters out any out-of-specification raw material before it can influence finished-tablet potency. Once the compression stage produces the finished 50 mg tablets, a statistically derived sample from each lot is pulled and quantified by HPLC against a certified Oxymetholone reference standard; the resulting potency figure is recorded on the batch certificate and is what backs the declared label claim. Separately, each lot clears LAL (Limulus Amebocyte Lysate) endotoxin testing — a quality step that applies equally to the oral solid-dose format as to injectable presentations within Dragon-Pharma's portfolio. The 100-tablet container itself is part of the presentation strategy: primary packaging is selected to protect tablet integrity against humidity and mechanical stress during transit, ensuring the dissolution profile verified at manufacture is maintained through to the point of use.

Product details

BrandDragon-Pharma
Active ingredientoxymetholone
Also known asAnadrol, Anapolon, Oxymetholone, Dragon-Pharma Anadrol
Strength50 mg
FormTabletten
Pack size100 pieces
Item numberORA-OXYM-DRA-005

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