Contraindications: Testosterone cypionate is contraindicated in individuals with known or suspected androgen-sensitive carcinoma of the prostate or male breast, active polycythaemia, untreated severe obstructive sleep apnoea, or hypersensitivity to any component of the formulation including the oil carrier. Individuals under 21 years of age should not use exogenous androgens due to potential premature closure of epiphyseal growth plates.
Side Effects: Common first-cycle adverse effects include acne (particularly on the back and shoulders), increased oiliness of the skin, temporary testicular atrophy resulting from HPG-axis suppression, and elevated estradiol leading to water retention or gynaecomastia if left unmanaged. Erythrocytosis (raised red blood cell count) is a dose-dependent risk requiring haematocrit monitoring throughout the cycle. Androgenic alopecia acceleration may occur in genetically predisposed individuals.
Monitoring: Beginners should complete bloodwork at baseline, at Week 4–5 of the cycle, and within two weeks of cycle completion. Key parameters: total testosterone, free testosterone, estradiol (sensitive assay), haematocrit, LH, FSH, PSA (if over 40), and a full lipid panel. Blood pressure should be self-monitored weekly given testosterone's fluid-retention potential.
PCT: Post-cycle therapy is mandatory after any suppressive testosterone cycle. Initiate SERM therapy approximately two to three weeks after the final injection. A standard beginner PCT protocol is nolvadex (tamoxifen) 20mg daily for six weeks, or clomiphene 25–50mg daily for the same duration. Do not skip PCT — HPG-axis suppression from a 10–12 week first cycle can persist for 8–16 weeks without pharmacological intervention.