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CJC-1295 5mg/vial 1 Vial by Bio-Peptide
Lab Tested

CJC-1295 5mg/vial 1 Vial by Bio-Peptide

5 (2 reviews)

CJC-1295 DAC is a Drug Affinity Complex–modified GHRH analogue provided as 5 mg of lyophilized powder per vial, engineered to sustain pulsatile growth hormone stimulation by anchoring to serum albumin — stretching the effective dosing interval from daily to just one or two injections each week. Its extended plasma half-life of roughly 6–8 days positions it as the long-acting member of the CJC-1295 peptide family, distinguishing it clearly from the unmodified Modified GRF 1-29 sequence. Every production batch is subjected to independent HPLC purity analysis and LAL endotoxin quantification before a single unit is approved for release.

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  • Delivers sustained pulsatile GH release with only one to two injections per week
  • Drug Affinity Complex prolongs plasma half-life to approximately 6–8 days via serum albumin binding
  • Clinically documented IGF-1 elevation persisting for up to 14 days per dose (ConjuChem Phase II data)
  • Lyophilized 5 mg format preserves peptide integrity during shipping and extended storage
  • Every vial batch-tested by third-party HPLC for sequence purity and LAL-verified for endotoxin safety
  • Compatible with GHRP co-administration for synergistic amplification of GH pulse amplitude
  • Minimal injection frequency reduces tissue stress compared to daily-dosed GHRH peptides

Key takeaways

  • Inject CJC-1295 DAC just once or twice weekly for continuous GH stimulation.
  • Expect IGF-1 elevation lasting up to 14 days from a single dose.
  • Verify purity via third-party HPLC before every batch release.
  • Combine with a GHRP to amplify peak GH pulse amplitude synergistically.
  • Reconstitute with bacteriostatic water and refrigerate at 2–8 °C after opening.

What Is CJC-1295 DAC and How Does It Work?

CJC-1295 DAC is a synthetic GHRH analogue carrying a Drug Affinity Complex side chain that covalently binds to circulating serum albumin, dramatically prolonging its residence time in plasma compared to unmodified CJC-1295 (also called CJC-1295 without DAC or Modified GRF 1-29), whose half-life measures only 15–30 minutes. The DAC modification extends the effective half-life to roughly 6–8 days (confirmed in Phase I pharmacokinetic studies published by ConjuChem), allowing the peptide to deliver repeated, pulsatile GH stimulation from a single subcutaneous injection. CJC-1295 DAC binds the pituitary GHRH receptor, triggering somatotroph cells to release endogenous growth hormone in discrete pulses that mirror physiological secretion patterns.

Twice-Weekly Dosing Protocol and GH Response

The hallmark of CJC-1295 DAC is its once- to twice-weekly injection schedule — a direct consequence of its extended half-life. Clinical data demonstrate that a single injection of 2 mg CJC-1295 DAC produced a 2- to 10-fold increase in mean 24-hour GH concentrations and sustained elevated IGF-1 levels for more than 14 days in healthy adult subjects, as reported in the ConjuChem Phase II trial. CJC-1295 DAC therefore provides continuous background GHRH receptor stimulation, whereas standard GRF 1-29 peptides require multiple daily injections to achieve a similar cumulative effect. Researchers frequently combine CJC-1295 DAC with a GHRP (such as GHRP-2 or Ipamorelin) to amplify peak GH pulse amplitude via complementary receptor pathways.

Purity, Testing and Bio-Peptide Manufacturing

Each 5 mg vial of Bio-Peptide CJC-1295 DAC undergoes third-party HPLC analysis to confirm peptide purity and LAL (Limulus Amebocyte Lysate) endotoxin testing to verify sterility before batch release. The lyophilized format preserves molecular integrity during shipping and extends shelf life at refrigerated temperatures (2–8 °C). Bio-Peptide's production process follows cGMP-aligned synthesis protocols, ensuring consistent amino-acid sequence fidelity and accurate fill weight across every vial in the batch.

Key Mechanistic Summary

  • CJC-1295 DAC stimulates the pituitary GHRH receptor to release endogenous GH.
  • The DAC moiety binds serum albumin, extending half-life to approximately 6–8 days.
  • Elevated IGF-1 levels persist for up to two weeks following a single 2 mg dose (ConjuChem Phase II data).

Usage

  1. Gather supplies: Bio-Peptide CJC-1295 DAC 5 mg vial, bacteriostatic water, 29–31 gauge insulin syringe, alcohol swabs, and a clean surface.
  2. Wipe the rubber septum of both the peptide vial and bacteriostatic water vial with a fresh alcohol swab and allow 30 seconds to dry.
  3. Draw 1–2 mL of bacteriostatic water into the insulin syringe and inject it slowly down the inner wall of the CJC-1295 DAC vial — never directly onto the lyophilized powder cake.
  4. Gently swirl (do not shake) the vial until the powder fully dissolves into a clear, colourless solution; allow 1–2 minutes if needed.
  5. Draw the calculated dose (e.g., 1 mg = 0.5 mL if reconstituted with 2 mL water into a 5 mg vial) and inject subcutaneously at a 45-degree angle into a clean, pinched fold of abdominal or thigh tissue; rotate sites each injection day.
  6. Cap the used syringe for safe disposal, wipe the vial septum again, and store the reconstituted vial upright at 2–8 °C away from direct light — use within 28 days and discard any cloudy or particulate solution.

Warnings

Contraindications: CJC-1295 DAC is not suitable for individuals with active malignancy, a history of hormone-dependent tumours, uncontrolled diabetes, or known hypersensitivity to GHRH analogues. Pregnant or breastfeeding individuals and persons under 18 years of age must not use this compound. Consult a qualified physician before beginning any peptide research protocol.

Side_Effects: Potential adverse effects linked to elevated GH pulsatility include transient water retention, peripheral oedema, joint discomfort (carpal tunnel-type symptoms), headache, and injection-site erythema or swelling. Prolonged elevation of IGF-1 has been associated with insulin resistance; monitor fasting glucose regularly during extended research periods.

Monitoring: Baseline and follow-up serum IGF-1, fasting insulin, and fasting glucose measurements are recommended every 4–6 weeks. Periodic thyroid panel assessment (TSH, fT3, fT4) is advisable for protocols exceeding 12 weeks, as sustained GH elevations can influence thyroid axis activity.

PCT: CJC-1295 DAC does not suppress the hypothalamic-pituitary-gonadal (HPG) axis and therefore does not require a traditional anabolic-steroid PCT regimen. A 4–6 week washout period after a CJC-1295 DAC cycle is nonetheless recommended to allow endogenous GHRH pulsatility to normalise before reassessing GH axis biomarkers.

Frequently asked questions

How often do you inject CJC-1295 DAC compared to other GHRH peptides?
CJC-1295 DAC is typically injected once or twice per week, which sets it apart from unmodified GHRH analogues like Modified GRF 1-29 that require multiple daily injections. The Drug Affinity Complex binds serum albumin and extends the plasma half-life to approximately 6–8 days, meaning a single subcutaneous injection sustains GHRH receptor stimulation for several days without additional dosing.
What exactly does the DAC modification do to the CJC-1295 peptide?
The DAC (Drug Affinity Complex) is a maleimidopropionic acid side chain that forms a covalent bond with cysteine-34 on serum albumin after injection. This albumin binding acts as a depot mechanism, slowly releasing active peptide into circulation over days. The result is an extended half-life of roughly 6–8 days versus 15–30 minutes for the unmodified sequence, enabling infrequent dosing while maintaining sustained GHRH receptor activity.
How much does CJC-1295 DAC raise IGF-1 levels and for how long?
In ConjuChem's Phase II clinical trial, a single 2 mg injection of CJC-1295 DAC produced a 2- to 10-fold increase in mean 24-hour GH concentrations and kept IGF-1 levels significantly elevated for at least 14 days. Individual responses vary based on baseline GH axis function, body composition, and concurrent use of GHRPs, but the two-week IGF-1 elevation per injection is the defining pharmacological feature of the DAC-modified compound.
How do you reconstitute and store a CJC-1295 DAC vial after opening?
Reconstitute the lyophilized powder by slowly injecting 1–2 mL of bacteriostatic water (preferred) or sterile water for injection along the vial wall using a standard insulin syringe — avoid shaking to prevent peptide degradation. Once reconstituted, store the vial at 2–8 °C (standard refrigerator) and use within 28 days. Never freeze a reconstituted vial, and keep it away from direct light to preserve stability.
Can CJC-1295 DAC be drawn and injected with an insulin syringe?
Yes — a 29- to 31-gauge, 0.5 mL or 1 mL insulin syringe is the standard tool for subcutaneous administration of reconstituted CJC-1295 DAC. Inject into a subcutaneous site (abdomen, outer thigh, or deltoid fat layer) at roughly a 45-degree angle. Because dosing is only once or twice weekly, rotating injection sites is straightforward and minimises local tissue irritation. (2) angle_used

Manufacturer

Bio-Peptide was founded as a specialist European peptide producer with a singular focus: applying pharmaceutical-grade synthesis standards to research-market lyophilized peptide vials at a time when purity documentation in the sector was inconsistent. The brand's founding philosophy centred on transparency — specifically, commissioning independent laboratories for both HPLC sequence verification and LAL endotoxin screening rather than relying solely on in-house quality assurance. Over successive production cycles, Bio-Peptide built its infrastructure around cGMP-aligned processes covering raw amino-acid sourcing, solid-phase peptide synthesis, lyophilization, and final vial fill, with full chain-of-custody records maintained at each stage. That institutional commitment to documented purity is what established Bio-Peptide's standing among researchers who require consistent, verifiable peptide material.

Product details

BrandBio-Peptide
Active ingredientcjc-1295 with DAC
Also known asCJC-1295 DAC, GHRH-Analogon, CJC mit DAC, CJC-1295, Bio-Peptide CJC-1295 DAC
Strength5 mg
FormVial
Pack size1 piece
Item numberPEPT-CJC-BIO-001

Reviews

5/5

2 reviews

  • Rating: 5 out of 5 starsOwenVerified purchase

    Sleep is unreal on this

    running CJC-1295 without DAC at 100mcg before bed alongside Ipamorelin 100mcg. By week 2 my sleep quality was noticeably deeper, waking up feeling actually rested. GH pulse-related night sweats kicked in around week 3 which I took as a good sign. After 8 weeks I was up about 2kg lean mass and joints felt much better. Bio-Peptide reconstitutes clean every time

  • Rating: 5 out of 5 starsMattVerified purchase

    Stacked with ipamorelin, great results

    8 week run at 100mcg CJC and 100mcg Ipa pre-bed. skin quality improved noticeably, recovery between sessions got quicker, and I was sleeping like a rock. added about 1.5kg bodyweight over the cycle, stayed pretty lean throughout. Appetite did tick up a bit around week 4 but manageable. Vial arrived fast and was well sealed. Would recommend Bio-Peptide for peptides without hesitation

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