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Cardarine 15mg/tab 50 Tabletten by Rich Piana 5% Nutrition
HPLC Verified

Cardarine 15mg/tab 50 Tabletten by Rich Piana 5% Nutrition

5 (2 reviews)

Cardarine (GW-501516) is a PPARδ agonist often grouped alongside SARMs in research discussions — yet unlike classic androgenic–anabolic steroids, it exerts no direct androgen receptor binding, making tissue selectivity the defining distinction between these compound classes. Each tablet in this Rich Piana 5% Nutrition blister delivers a precisely measured 15 mg dose, the highest per-unit concentration currently available in this catalog for GW-501516. Batch identity and purity are confirmed through HPLC chromatography; every lot reaching the consumer has passed quantitative potency analysis before release.

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  • 15 mg per tablet — the highest per-unit GW-501516 concentration in this catalog, reducing daily pill count.
  • PPARδ agonism mechanism operates outside the androgen receptor, avoiding steroid-class androgenic effects.
  • HPLC-Verified potency: quantitative chromatography confirms label-claimed content before release.
  • 50-tablet blister pack supports a complete 7–10 week research protocol without mid-cycle reorder.
  • No 17α-alkylation in the GW-501516 molecule — liver toxicity risk profile differs structurally from oral AAS.
  • Rich Piana 5% Nutrition's production quality control applies both HPLC and microbiological testing per batch.
  • Single-unit dosing at the research-relevant upper range (15 mg) eliminates tablet-splitting variance.

Key takeaways

  • Distinguish GW-501516's PPARδ mechanism from androgen-receptor–based SARMs and AAS.
  • Verify every batch: HPLC chromatography confirms the 15 mg stated dose.
  • Choose 15mg/tab format to eliminate splitting errors at upper research doses.
  • Expect no androgenic suppression pathway — GW-501516 bypasses the HPTA axis.
  • Review rodent carcinogenicity data before committing to long-duration protocols.

What Separates GW-501516 from SARMs and Steroids?

Cardarine (GW-501516) operates through PPARδ agonism rather than androgen receptor modulation, placing it in a mechanistically distinct category from both classic androgenic–anabolic steroids (AAS) and Selective Androgen Receptor Modulators (SARMs). Classic AAS bind androgen receptors systemically — in muscle, prostate, liver, and sebaceous tissue alike — producing the well-documented androgenic side-effect profile: virilization, HPTA suppression, hepatotoxicity (especially 17α-alkylated orals), and cardiovascular lipid disruption. SARMs were engineered to retain anabolic receptor signaling in skeletal muscle while reducing androgenic activity in reproductive and dermal tissues, but tissue selectivity in SARMs is partial, not absolute. GW-501516 bypasses the androgen receptor entirely, targeting fatty-acid oxidation gene cascades via PPARδ, which means standard androgenic side effects tied to testosterone mimicry are structurally absent from its mechanism.

Tissue Selectivity: Where the Science Stands

Selective androgen receptor modulators achieve selectivity through differential receptor co-activator recruitment in different tissues — a mechanism that is real but incomplete, as anecdotal and preclinical data confirm residual suppression of the hypothalamic–pituitary–testicular axis (HPTA) at research-relevant doses. Compared to AAS, SARMs produce meaningfully lower androgenic burden; compared to GW-501516, SARMs still involve direct AR signaling. Rich Piana 5% Nutrition Cardarine delivers 15 mg of GW-501516 per tablet, confirmed by HPLC quantitative analysis, providing a dose unit that aligns with the upper boundary documented in human pharmacokinetic case reports (10–20 mg/day range). The selectivity advantage of GW-501516 over both AAS and SARMs lies specifically in the absence of androgen-mediated suppression, though rodent carcinogenicity studies at supratherapeutic doses remain an active discussion in research communities.

Dosing Precision and HPLC Verification

Rich Piana 5% Nutrition subjects each production batch to HPLC (High-Performance Liquid Chromatography) verification; the 15 mg stated on the label reflects the analytically confirmed content per tablet, not a nominal target. Fifty tablets per blister pack support a standard 7–10 week research protocol without mid-cycle resupply. For users modeling SARMs-comparison research designs, a single 15 mg tablet covers the full upper research dose in one unit, eliminating the splitting errors that introduce dosing variance in lower-concentration formats.

Key Mechanism Summary

  • GW-501516 activates PPARδ, upregulating genes governing mitochondrial fatty-acid oxidation.
  • Classic AAS suppress HPTA through androgen receptor–mediated negative feedback at the hypothalamus.
  • SARMs reduce but do not eliminate androgenic receptor signaling in non-target tissues.

Usage

  1. Review your baseline bloodwork — record lipid panel (LDL/HDL), liver enzymes (ALT/AST), and fasting glucose before the first tablet, establishing a comparison reference point.
  2. Begin with a reduced dose during orientation weeks: take ½ tablet or use an alternating-day schedule with the full 15 mg unit if splitting is impractical.
  3. Advance to one full 15 mg tablet daily from week 3 onward; take with a meal containing dietary fat to support consistent GI absorption.
  4. Maintain consistent daily timing — GW-501516's half-life (~16–24 hours) supports once-daily dosing without peak-trough stacking.
  5. Log subjective and performance markers weekly; because this compound differs mechanistically from SARMs and AAS, androgenic endpoints (libido, mood, skin oiliness) are not primary monitoring targets — cardiovascular and lipid markers are.
  6. After the final tablet, schedule a follow-up lipid panel and liver enzymes at the 2-week post-cycle mark; no standard PCT is mechanistically indicated for GW-501516, but confirm hormonal baselines as a precaution.

Warnings

Contraindications: Not for use by individuals under 18 years of age, pregnant or nursing women, or anyone with a history of hormone-sensitive cancers. GW-501516 produced dose-dependent tumor development in multiple organ systems in long-term rodent studies at supratherapeutic doses; this finding is a mandatory disclosure regardless of mechanism. Persons with pre-existing hepatic impairment or dyslipidemia should seek physician clearance before use.

Side_Effects: Unlike AAS, virilization, gynecomastia, and androgenic acne are not mechanistically expected with GW-501516. Reported adverse signals in case literature include HDL suppression at prolonged higher doses and gastrointestinal discomfort. The carcinogenicity signal observed in rodent models has not been replicated in controlled human clinical data, but no long-duration human safety trial exists.

Monitoring: Obtain a full lipid panel (LDL, HDL, triglycerides), fasting glucose, and liver enzyme panel (ALT, AST, GGT) before, mid-cycle (week 4), and post-cycle (week 10+). Unlike SARM or AAS monitoring, LH/FSH tracking is not a primary endpoint; cardiovascular markers and inflammatory indices (hsCRP) are more relevant for PPARδ-acting compounds.

PCT: Post-Cycle Therapy (standard SERM-based protocol) is not mechanistically required because GW-501516 does not suppress the HPTA via androgen-receptor feedback. If stacked with SARMs or AAS in the same cycle, PCT requirements are determined by the androgen-receptor–active compounds in that stack, not by GW-501516 itself.

Frequently asked questions

How does tissue selectivity in SARMs actually differ from the broad androgenic action of classic steroids?
Classic anabolic–androgenic steroids bind androgen receptors throughout the body — muscle, prostate, liver, and skin — producing systemic effects. SARMs exploit differential co-activator protein recruitment to favor muscle and bone receptors over prostate and sebaceous tissue receptors. This selectivity is real but partial: HPTA suppression and residual androgenic activity in non-target tissues are still reported, particularly at doses above 10 mg/day.
Does Cardarine GW-501516 suppress testosterone like SARMs or steroids do?
No — Cardarine does not interact with the androgen receptor and therefore does not trigger the androgen-receptor–mediated negative feedback loop responsible for testosterone suppression in both AAS and SARM use. Its PPARδ agonism mechanism bypasses the hypothalamic–pituitary–testicular axis entirely, meaning standard post-cycle HPTA recovery protocols are not mechanistically required, though individual monitoring is always advisable.
Where does SARM tissue selectivity break down compared to what manufacturers claim?
SARM tissue selectivity breaks down primarily at higher doses and with prolonged exposure. Preclinical and user-reported data indicate that LH and FSH suppression — signals of HPTA interference — occur even with 'selective' compounds like Ostarine at 25 mg/day or Ligandrol at 10 mg/day. The selectivity ratio improves at lower doses but never reaches zero androgenic activity in all non-skeletal tissues, unlike PPARδ agonists such as GW-501516.
Why does Rich Piana 5% Nutrition offer Cardarine at 15mg per tablet when many competitors use 10mg?
The 15 mg per tablet format allows researchers and advanced users to cover the upper end of the documented human-use range (10–20 mg/day) in a single, HPLC-verified unit. This eliminates the compounding dosing errors that occur when splitting 10 mg tablets to achieve a 15 mg dose, and reduces daily pill burden for protocols requiring the higher-end dose across a 7–10 week cycle with 50 tablets per blister.
Can Cardarine 15mg tablets be split to achieve a lower 7.5mg dose for a cautious starting protocol?
Splitting is physically possible if the tablet is uncoated and scored, but it introduces dose-variance risk. The preferred approach for a lower starting dose is to use a 10 mg product and dose once daily, or use the 15 mg tablet on alternating days under medical guidance. Rich Piana 5% Nutrition's HPLC verification applies to the whole tablet unit; half-tablet dosing accuracy depends on consistent homogeneous API distribution in the manufacturing process. (2) angle_used

Manufacturer

Rich Piana 5% Nutrition built its reputation on transparency in formulation — a standard extended into its research compound line through mandatory batch-level HPLC (High-Performance Liquid Chromatography) analysis. For this Cardarine product, quantitative HPLC chromatography verifies that each tablet contains the label-declared 15 mg of GW-501516 before the blister pack enters distribution. Microbiological safety evaluation complements potency testing, ensuring that the finished product meets acceptable limits for bioburden and endotoxin load. The company's quality framework integrates these laboratory steps as release criteria, not optional audits — a commitment that underpins the HPLC-Verified badge carried by this SKU.

Product details

BrandRich Piana 5% Nutrition
Active ingredientcardarine
Also known asGW-501516, Endurobol, Cardarine, Rich Piana 5% Nutrition GW-501516
Strength15 mg
FormTabletten
Pack size50 pieces
Item numberSARM-CARD-RIC-002

Reviews

5/5

2 reviews

  • Rating: 5 out of 5 starspumpchaser35Verified purchase

    does what it says

    15mg ed, 10 week cut. Lost 6kg, kept every bit of muscle. Endurance in the gym is unreal, longer sessions with no gas out. Will reorder

  • Rating: 5 out of 5 starstitan_24Verified purchase

    Top tier cardarine

    Used a few brands before and this 5% Nutrition one hits harder. Running 15mg daily, by week 3 my resting heart rate actually dropped 4bpm and I'm doing 45min HIIT sessions that would've killed me before. Body recomp has been visible, down 5kg in 9 weeks with lifts going up. Delivery was quick and the tabs are uniform, no crumbly nonsense

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