Contraindications: Not for use by individuals under 18 years of age, pregnant or breastfeeding women, or those with pre-existing hepatic impairment, prostatic hypertrophy, or cardiovascular disease including dyslipidaemia. The 17α-alkyl structure places an inherent hepatic burden on liver enzyme pathways; confirmed liver pathology is an absolute contraindication regardless of dose or duration.
Side Effects: Potential adverse effects include suppression of endogenous testosterone production, elevation of liver transaminases (ALT/AST) detectable by standard hepatic panels, unfavourable shifts in lipid profile (LDL elevation, HDL reduction), and androgenic effects including acne and hair follicle sensitivity in predisposed individuals. Virilisation risk in female users is dose- and duration-dependent.
Monitoring: Baseline and mid-cycle liver function tests (ALT, AST, GGT) are recommended; values exceeding three times the upper reference limit indicate cycle interruption. Lipid panels should be assessed at the midpoint of cycles lasting six weeks or longer. Blood pressure monitoring at each week of use is advised given oral androgen effects on haematocrit and vascular tone.
PCT: Endogenous testosterone suppression necessitates a structured post-cycle therapy protocol beginning 3–5 days after the final tablet. Standard PCT employs selective oestrogen receptor modulators (SERMs) such as Tamoxifen or Clomiphene for four weeks to restore hypothalamic-pituitary-gonadal axis function. The short plasma clearance time of oral Chlordehydromethyltestosterone — approximately four to five days to near-complete washout — allows PCT to begin earlier than with long-ester injectable androgens.