Contraindications: Not indicated for individuals with pre-existing hepatic disease, cardiovascular risk factors including dyslipidaemia or hypertension, active androgenic alopecia requiring medical management, or anyone under 21 years of age. Contraindicated throughout pregnancy and lactation.
Side Effects: Hepatotoxicity risk is dose- and duration-dependent; elevated ALT/AST values are the primary biochemical marker to monitor. HDL suppression is consistent across oral anabolic exposure and may persist beyond cycle end. Androgenic effects including seborrhoea, accelerated hair thinning in genetically predisposed individuals, and virilisation in female users are concentration-dependent. Endogenous testosterone suppression is expected at any dose exceeding 10 mg daily for more than two weeks.
Monitoring: Baseline liver function panel (ALT, AST, GGT, bilirubin) and lipid profile before cycle start. Repeat hepatic panel at cycle midpoint and within seven days of the final dose. Blood pressure measurement weekly throughout the cycle. Full haematological and endocrine panel — including LH, FSH, and total testosterone — four weeks post-cycle to confirm HPG axis recovery trajectory.
PCT: Commence post-cycle therapy the day following the last tablet. SERM-based protocols (tamoxifen 20–40 mg daily for four weeks, or clomiphene 50 mg daily for three weeks) are standard. The decision between SERM types should account for individual lipid-sensitivity profiles, as clomiphene carries a more pronounced HDL impact in some users. Do not extend cycle length beyond eight weeks without re-evaluating hepatic transaminase levels.