Contraindications: Evogene must not be used by individuals with active malignancies, diabetic retinopathy, closed epiphyseal plates (adolescents under 18), untreated hypothyroidism, or acute critical illness. Individuals with pre-existing insulin resistance or type 2 diabetes should not initiate HGH therapy without endocrinological supervision, as somatropin raises fasting glucose through gluconeogenic mechanisms.
Side_Effects: Dose-dependent side effects include peripheral oedema (fluid retention in extremities), carpal tunnel syndrome due to connective tissue swelling, and transient joint aches — typically resolving with dose reduction. Prolonged use at supraphysiological doses may elevate IGF-1 beyond the physiological range; monitor serum IGF-1 every 8–12 weeks on-cycle. Lipohypertrophy at injection sites is preventable through consistent site rotation.
Monitoring: Obtain baseline fasting insulin, fasting glucose, HbA1c, and IGF-1 serum levels before starting. Repeat fasting glucose and IGF-1 at weeks 8 and 16. Blood pressure should be tracked monthly. Thyroid function (TSH, free T4) warrants assessment at 12 weeks, as HGH can suppress thyroid output in genetically susceptible individuals.
PCT: HGH does not suppress the hypothalamic–pituitary–gonadal (HPG) axis and therefore does not require classical post-cycle therapy (e.g., SERMs). However, when Evogene is stacked with anabolic steroids — a common fat-loss combination — PCT for the steroid component remains obligatory. Upon discontinuing HGH, endogenous GH secretion resumes within days; no taper is required, though gradual dose reduction is preferable over abrupt cessation in protocols exceeding 20 weeks.