Contraindications: Adipex RTD must not be used by individuals with cardiovascular disease, uncontrolled hypertension, hyperthyroidism, glaucoma, or a documented history of stimulant hypersensitivity. Concurrent use with MAO inhibitors or other sympathomimetic agents is absolutely contraindicated due to risk of hypertensive crisis. Pregnancy and lactation represent absolute contraindications; Phentermine is classified Pregnancy Category X.
Side Effects: Stimulant-class adverse effects include insomnia, elevated resting heart rate, dry mouth, and transient blood-pressure elevation — most pronounced during the first 1–2 weeks. CNS effects may include restlessness or reduced cognitive fatigue. Appetite suppression itself can mask dehydration signals; deliberate fluid intake scheduling is recommended. Dependence potential is classified as Schedule IV under US controlled-substance regulations.
Monitoring: Blood pressure and resting heart rate should be measured at baseline and at weeks 2, 6, and 12. Individuals with borderline hypertension require more frequent cardiovascular monitoring. Fasting blood glucose should be tracked in pre-diabetic users, as reduced caloric intake combined with Phentermine's sympathomimetic activity can alter glycaemic patterns. Discontinue immediately if chest pain, palpitations, or shortness of breath develop.
PCT: Phentermine is not androgenic and does not suppress the hypothalamic-pituitary-gonadal axis; formal post-cycle therapy targeting hormonal recovery is not applicable. However, a structured dietary re-entry protocol should follow cycle completion — maintaining a moderate deficit without pharmacological assistance and re-establishing normal meal frequency prevents rebound hyperphagia driven by post-cycle hunger rebounds.