What is the correct diluent for reconstituting ACE-031 (ACVR2B) peptide?

Bacteriostatic water containing 0.9 % benzyl alcohol is the preferred diluent for ACE-031. It provides preservative protection during multi-draw use over up to 28 days. Sterile saline or plain water for injection can be used but must be consumed quickly. Always inject the diluent slowly down the vial wall and swirl — never shake — to protect the protein structure.

How long does reconstituted ACE-031 stay stable in the refrigerator?

Once reconstituted, ACE-031 solution should be stored at 2–8 °C and used within 28 days. Freezing reconstituted solution is not advised because ice-crystal formation can fragment the ACVR2B-Fc fusion protein. Keep the vial upright, away from light, and inspect for cloudiness or particulates before each draw.

Which syringe size is recommended for subcutaneous ACE-031 injections?

A 29–31 gauge insulin syringe with a 0.5-inch needle is standard for subcutaneous peptide injections. This gauge minimises tissue trauma and is appropriate for abdominal or lateral thigh sites. Insert at 45° for leaner individuals and 90° for those with more subcutaneous depth, rotating sites each session to avoid localised tissue changes.

How many doses can I draw from a single Master Pharma ACE-031 10mg vial?

The number of doses depends on your chosen concentration. Reconstituting with 2 mL of bacteriostatic water yields 5 mg/mL; a 0.5 mg dose would then equal 0.1 mL per draw, giving approximately 20 draws per vial. Use a fresh needle for every draw to maintain sterility and avoid contaminating the remaining solution.

Can ACE-031 vials be transported without refrigeration, and how should they be packed?

Lyophilised (unreconstituted) ACE-031 vials tolerate short-term room temperature exposure (≤ 25 °C) during transit — typically up to 72 hours — without significant potency loss. For longer transport, pack vials in an insulated pouch with a gel ice pack. Once reconstituted, the solution must remain refrigerated and should never be transported unprotected. (2) angle_used

Pharma Grade

Master Pharma

ACVR2B 10mg/vial 1 Vial by Master Pharma

Name: ACVR2B (ACE-031)
Brand: Master Pharma
SKU: PEPT-ACE-MAS-002
Price: 60.00 EUR
Availability: InStock

ACE-031 (ACVR2B) is a recombinant fusion protein that suppresses activin-receptor signalling to promote skeletal muscle growth, supplied by Master Pharma as a lyophilised powder at 10 mg per vial — paired here with a practical guide to reconstitution, cold-chain storage, and subcutaneous injection. Proper handling is essential: lyophilised peptides must be reconstituted with bacteriostatic water, kept refrigerated at 2–8 °C, and injected subcutaneously with a fine insulin syringe. Quality is verified through HPLC-confirmed purity and LAL endotoxin testing; every vial leaving the Master Pharma facility meets Pharma Grade standards under GMP-compliant production protocols.

€60.00Free shipping on orders over €300

In stock

Ships within 48 h Lab-tested batch

Activin-receptor ligand suppression supports lean muscle accumulation beyond natural plateaus
Lyophilised format retains full potency throughout cold-chain distribution
Pharma Grade certification backed by HPLC purity analysis and LAL endotoxin testing
Bromobutyl rubber stopper enables safe multi-draw use without contamination
10 mg per vial allows flexible dosing increments for research protocols
GMP-compliant manufacturing ensures batch-to-batch consistency verified by third-party testing
Compatible with standard insulin syringes for straightforward subcutaneous self-administration

Phase	Dosage / Volume	Note
Vial Preparation	1–2 mL BAC water per 10 mg vial	Yields 5–10 mg/mL; inject diluent down inner vial wall, swirl gently
Initial Research Dose	0.1–0.3 mg per injection	Low starting point; assess tolerability before escalation
Exploratory Protocol	0.3–1.0 mg per session	Frequency typically once or twice weekly; rotate injection sites
Post-Reconstitution Storage	2–8 °C refrigeration	Use within 28 days; do not freeze reconstituted solution

Key takeaways

Reconstitute ACE-031 with bacteriostatic water, never plain saline.
Swirl the vial gently — shaking degrades the fusion protein.
Refrigerate reconstituted solution and use within 28 days.
Rotate subcutaneous injection sites each session to prevent tissue changes.
Verify Pharma Grade status via HPLC purity and LAL endotoxin certificates.

What Is ACE-031 and Why Does Handling Matter?

ACE-031 is a soluble recombinant ACVR2B-Fc fusion protein that binds circulating activin-receptor ligands and reduces the braking signals that limit muscle fibre growth — and because it is a large, fragile protein, correct handling from the moment the vial arrives determines both potency and safety. Unlike small-molecule compounds, peptide biologics degrade rapidly when exposed to heat, agitation, or contamination. Master Pharma supplies ACE-031 as a lyophilised (freeze-dried) white powder sealed under nitrogen, which stabilises the protein until the user is ready to reconstitute it.

Reconstitution: Step-by-Step

Bacteriostatic water (BAC water, 0.9 % benzyl alcohol) is the correct diluent for ACE-031; sterile water for injection is a secondary option but offers no preservative protection once opened. The recommended reconstitution volume is 1–2 mL per vial, yielding a concentration of 5–10 mg/mL depending on the user's preferred dose per injection. The diluent should be injected slowly down the inner wall of the vial — never squirted directly onto the powder cake — and the vial swirled gently rather than shaken, because mechanical agitation denatures tertiary protein structure. Compared to short-chain peptides such as BPC-157, ACE-031's larger molecular weight makes it more sensitive to both heat and shear stress during reconstitution.

Cold-Chain Storage and Shelf Life

Before reconstitution, lyophilised ACE-031 vials remain stable at room temperature (≤ 25 °C) for short transit periods but should be stored at 2–8 °C upon receipt. After reconstitution, the solution must be refrigerated continuously and used within 28 days; freezing a reconstituted solution is not recommended because ice-crystal formation can irreversibly fragment the Fc fusion domain. Each Master Pharma vial is sealed with a bromobutyl rubber stopper and aluminium crimp cap, verified by sterility testing to prevent microbial ingress during multi-draw use.

Subcutaneous Injection Technique

ACE-031 is administered subcutaneously using a 29–31 gauge, 0.5-inch insulin syringe. The injection site — typically the abdomen, lateral thigh, or deltoid fold — should be cleaned with an alcohol swab and allowed to dry for 10 seconds before insertion. The needle is inserted at a 45° angle for lean individuals or 90° for those with greater subcutaneous tissue depth. Rotating sites prevents localised lipoatrophy. Dosing in research contexts has ranged from 1 mg/kg in single-dose Phase 1 settings (Acceleron Pharma clinical documentation) to lower exploratory doses in ongoing investigations.

Usage

Remove the vial from refrigeration 10 minutes before use to allow it to reach room temperature, reducing injection discomfort.
Clean the rubber stopper with a fresh alcohol swab and allow it to air-dry for 10 seconds before piercing.
Draw 1–2 mL of bacteriostatic water into a fresh syringe and inject it slowly down the inner wall of the vial — not directly onto the powder cake.
Swirl the vial gently in a circular motion for 30–60 seconds until the powder is fully dissolved; discard if cloudiness or particulates remain.
Draw the required dose volume into a 29–31 gauge insulin syringe, expel any air bubbles, and clean the subcutaneous injection site (abdomen, thigh, or deltoid fold) with an alcohol swab.
Insert the needle at 45–90° depending on subcutaneous tissue depth, inject slowly, withdraw, and apply gentle pressure with a dry swab; record the injection site and rotate next session.

Warnings

Contraindications: ACE-031 is not approved for human therapeutic use by any regulatory authority (FDA, EMA). It is contraindicated in individuals with known hypersensitivity to recombinant Fc-fusion proteins, active cardiovascular disease, bleeding disorders, or pregnancy. Do not use alongside other activin-pathway modulators without specialist oversight.

Side Effects: Clinical investigation data identified epistaxis (nosebleeds), gingival bleeding, telangiectasias, and injection-site erythema as reported adverse events. Vascular effects are attributed to activin/BMP pathway interference in endothelial tissues. Users should monitor for unexplained bruising or mucosal bleeding.

Monitoring: Baseline and on-cycle haematological panels — including platelet count, PT/INR, and haemoglobin — are advisable. Liver enzyme screening (ALT, AST) and cardiovascular assessment should be conducted periodically throughout any research protocol.

PCT: No established PCT protocol exists for ACVR2B peptides; however, given potential suppression of GDF-11 and activin signalling, a supervised return-to-baseline monitoring period of four to eight weeks post-cycle is prudent before initiating any further peptide or hormonal compound.

Frequently asked questions

What is the correct diluent for reconstituting ACE-031 (ACVR2B) peptide?: Bacteriostatic water containing 0.9 % benzyl alcohol is the preferred diluent for ACE-031. It provides preservative protection during multi-draw use over up to 28 days. Sterile saline or plain water for injection can be used but must be consumed quickly. Always inject the diluent slowly down the vial wall and swirl — never shake — to protect the protein structure.
How long does reconstituted ACE-031 stay stable in the refrigerator?: Once reconstituted, ACE-031 solution should be stored at 2–8 °C and used within 28 days. Freezing reconstituted solution is not advised because ice-crystal formation can fragment the ACVR2B-Fc fusion protein. Keep the vial upright, away from light, and inspect for cloudiness or particulates before each draw.
Which syringe size is recommended for subcutaneous ACE-031 injections?: A 29–31 gauge insulin syringe with a 0.5-inch needle is standard for subcutaneous peptide injections. This gauge minimises tissue trauma and is appropriate for abdominal or lateral thigh sites. Insert at 45° for leaner individuals and 90° for those with more subcutaneous depth, rotating sites each session to avoid localised tissue changes.
How many doses can I draw from a single Master Pharma ACE-031 10mg vial?: The number of doses depends on your chosen concentration. Reconstituting with 2 mL of bacteriostatic water yields 5 mg/mL; a 0.5 mg dose would then equal 0.1 mL per draw, giving approximately 20 draws per vial. Use a fresh needle for every draw to maintain sterility and avoid contaminating the remaining solution.
Can ACE-031 vials be transported without refrigeration, and how should they be packed?: Lyophilised (unreconstituted) ACE-031 vials tolerate short-term room temperature exposure (≤ 25 °C) during transit — typically up to 72 hours — without significant potency loss. For longer transport, pack vials in an insulated pouch with a gel ice pack. Once reconstituted, the solution must remain refrigerated and should never be transported unprotected. (2) angle_used

Manufacturer

Master Pharma introduced its ACVR2B (ACE-031) product line as part of a focused expansion into recombinant peptide biologics — a category requiring substantially different manufacturing infrastructure than conventional synthetic peptides. The ACE-031 vial represents an early flagship in that line: produced under GMP-audited conditions, each batch undergoes HPLC identity and purity profiling alongside LAL (Limulus Amebocyte Lysate) endotoxin testing before release. The lyophilisation process used for this product was specifically selected to preserve Fc-fusion protein integrity during distribution, reflecting Master Pharma's commitment to cold-chain-stable research compounds.

Product details

Brand	Master Pharma
Active ingredient	ace-031
Also known as	Myostatin-Inhibitor, Bio-Peptide ACE-031, ACVR2B (ACE-031), Master Pharma Myostatin-Inhibitor
Strength	10 mg
Form	Vial
Pack size	1 piece
Item number	PEPT-ACE-MAS-002

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