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Myostine 5mg/tab 30 Tablets by Vital Research
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Myostine 5mg/tab 30 Tablets by Vital Research

Myostine (YK-11) is a steroidal SARM that binds androgen receptors with tissue-selective affinity while simultaneously inhibiting myostatin — a mechanistic dual-action that distinguishes it sharply from classical anabolic-androgenic steroids. Each tablet delivers a precision 5 mg dose of YK-11, giving researchers a high-concentration oral format purpose-built for selectivity studies. Third-party verified: every 30-tablet blister lot released by Vital Research carries HPLC-confirmed potency and an LAL endotoxin clearance certificate under GMP-aligned production controls.

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  • Dual anabolic mechanism: androgen receptor activation plus myostatin suppression via Follistatin induction
  • Steroidal SARM backbone delivers high AR binding affinity at research-grade doses
  • 5 mg/tablet concentration supports whole-tablet titration across a 5–15 mg/day protocol
  • HPLC-confirmed YK-11 content — potency verified against reference standard before release
  • LAL endotoxin clearance on every batch — microbiological safety documented, not assumed
  • Individual 30-tablet blister with unique lot code enables full certificate-of-analysis traceability
  • Narrower androgenic footprint in non-target tissues compared to equivalent doses of testosterone

Key takeaways

  • Understand how YK-11 achieves tissue selectivity through biased AR co-activator recruitment.
  • Compare YK-11's dual AR-plus-myostatin mechanism against single-pathway classic steroids.
  • Monitor liver enzymes during research — selectivity does not eliminate hepatic risk.
  • Leverage 5mg tablet strength for clean titration without splitting.
  • Verify every batch: HPLC potency and LAL endotoxin certificates ship with each lot.

YK-11 as a Selective Androgen Receptor Modulator: What 'Selective' Really Means

Myostine (YK-11) occupies a structurally unique position in SARM pharmacology: it is a synthetically derived steroidal compound that activates androgen receptors through tissue-biased agonism rather than the systemic, non-discriminating receptor saturation characteristic of classical AAS. In practical terms, selectivity means that YK-11 recruits co-activator proteins preferentially in muscle and bone tissue rather than in the prostate, sebaceous glands, or the hypothalamic–pituitary axis — the primary sites of androgen-related adverse effects in steroid users. This receptor-biased signaling is the mechanistic foundation that separates SARMs from traditional steroids at a molecular level.

SARMs vs. Classic AAS: The Selectivity Trade-Off

Compared to testosterone or nandrolone, YK-11 demonstrates a narrower receptor activation footprint — binding androgen receptors with high affinity (Ki in the low-nanomolar range in preclinical assays) while producing measurably less androgenic signal in tissues that express 5-alpha reductase. YK-11 additionally functions as a partial Follistatin inducer, suppressing myostatin activity; this myostatin-inhibiting pathway operates independently of direct AR agonism, a dual mechanism not observed in classical AAS. Where steroids exert anabolic effects almost entirely through AR saturation plus aromatase conversion, YK-11 adds a second anabolic vector without the estrogenic cascade. The selectivity advantage, however, is relative — at research-grade doses, suppression of endogenous testosterone production remains a documented pharmacodynamic consequence, shared with conventional androgens.

Where Tissue Selectivity Has Documented Limits

No current SARM achieves complete organ selectivity. Vital Research formulates each 5 mg Myostine tablet to allow controlled, consistent dosing — HPLC quantification confirms active YK-11 content against a reference standard, and LAL (Limulus Amebocyte Lysate) endotoxin testing validates microbiological safety batch-by-batch. Researchers using YK-11 should note that liver transaminase elevation has been observed in in-vitro hepatocyte studies, suggesting a hepatotoxic liability comparable in mechanism — if not magnitude — to 17-alpha-alkylated oral steroids. Monitoring liver enzymes (ALT/AST) remains a standard protocol recommendation regardless of the compound's SARM classification.

Dosing Format and Research Utility

The 5 mg/tablet concentration is the highest single-tablet dose available in this Vital Research SARM series, enabling flexible titration across a 5–15 mg/day research range without compound tablet splitting. Thirty tablets per blister provides a standard four-to-six-week supply at common research protocols. GMP-aligned manufacturing ensures content uniformity across all 30 tablets — critical when dose precision determines the validity of selectivity-focused research outcomes.

Usage

  1. Establish your research objective — selectivity comparison studies benefit from a fixed single daily dose; begin at 5 mg to document baseline androgenic and anabolic response.
  2. Administer the tablet orally with a small meal; YK-11's steroidal structure confers reasonable oral bioavailability, though consistent fed-state timing reduces inter-day variability.
  3. Record dose timing precisely — the estimated half-life of YK-11 is approximately 6–10 hours, suggesting twice-daily splitting (e.g. 5 mg AM / 5 mg PM) may sustain more consistent plasma levels at 10 mg/day protocols.
  4. Draw baseline bloods before Week 1: include total testosterone, LH, FSH, ALT, AST, and haematocrit — these establish the pre-research reference points against which SARM-related changes are measured.
  5. Re-test at Week 4 (mid-protocol): HPG suppression markers and liver enzymes are the critical selectivity-vs.-steroid comparison data points — document deviations from baseline.
  6. Upon protocol completion, initiate PCT within 24–48 hours of the final tablet; the steroidal SARM classification of YK-11 warrants a structured post-cycle approach rather than the watchful waiting sometimes applied to non-steroidal SARMs.

Warnings

Contraindications: Not intended for human consumption. Contraindicated in individuals with existing hepatic dysfunction, active cardiovascular disease, or hormone-sensitive conditions. Not suitable for use by anyone under 18, or by pregnant or breastfeeding individuals.

Side Effects: Documented pharmacodynamic risks include HPG-axis suppression (reduced LH, FSH, endogenous testosterone), potential hepatotoxic stress at higher doses based on in-vitro hepatocyte data, and androgenic effects in hormone-sensitive tissues despite the compound's partial selectivity advantage over classical AAS.

Monitoring: Baseline and mid-protocol blood panels are strongly recommended: liver function tests (ALT, AST), full hormonal panel (total testosterone, LH, FSH), and haematocrit. Liver enzyme elevation exceeding 2× upper normal limit warrants immediate protocol suspension.

PCT: Post-cycle support is required following YK-11 research protocols. The steroidal SARM mechanism produces HPG suppression comparable to moderate-dose androgen use; structured PCT using SERMs (e.g. Nolvadex or Clomid) is the standard pharmacological approach to restore endogenous testosterone production.

Frequently asked questions

What does 'tissue selectivity' actually mean when comparing YK-11 to anabolic steroids?
Tissue selectivity means YK-11 preferentially activates androgen receptors in muscle and bone by recruiting specific co-activator proteins, rather than triggering uniform receptor saturation across all androgen-sensitive tissues as classical AAS do. In practice, this reduces androgenic signalling in the prostate and scalp relative to an equivalent anabolic dose of testosterone — though selectivity is partial, not absolute.
Are SARMs like Myostine genuinely safer than traditional steroids in terms of side effects?
SARMs carry a narrower documented side-effect profile in certain tissues — reduced aromatization risk and lower androgenic signal in non-target organs — but 'safer' is dose- and context-dependent. YK-11 still suppresses the hypothalamic–pituitary–gonadal axis and shows hepatocyte stress in vitro, meaning liver monitoring and post-cycle support remain necessary, just as with conventional androgens.
Where does the tissue selectivity of YK-11 break down compared to other SARMs?
YK-11's steroidal backbone makes its selectivity profile less clean than non-steroidal SARMs such as Ostarine. Preclinical data indicate stronger AR binding affinity but also a higher likelihood of HPG-axis suppression and potential hepatotoxic liability — areas where classical selectivity advantages erode. Researchers should treat YK-11 as occupying the high-potency, moderate-selectivity segment of the SARM spectrum.
Why is 5mg per tablet significant for dosing precision with Myostine?
At 5 mg/tablet, Vital Research Myostine is the highest per-tablet concentration in the series, allowing researchers to achieve a 5, 10, or 15 mg daily dose using whole tablets — no splitting required. This preserves content uniformity validated by HPLC testing and eliminates dose inconsistency introduced by manual tablet division.
How does the blister format of Myostine 30 tablets support accurate research protocols?
Each 30-tablet blister carries a unique lot code linked to a compound-specific certificate of analysis documenting HPLC-verified YK-11 potency and LAL endotoxin results. Individual blister sealing under GMP-aligned conditions protects tablet integrity from moisture and oxidation, ensuring dose consistency from tablet one through tablet thirty across the full research cycle. (2) angle_used

Manufacturer

Vital Research's distribution and logistics model is organized around compound-specific blister units shipped with their individual quality documentation — each 30-tablet Myostine blister leaves the facility paired with a lot-specific certificate of analysis rather than a generic facility-wide quality statement. Order fulfillment is structured to maintain cold-chain compatibility where required, and discrete, tamper-evident outer packaging protects product integrity during transit. Traceability is embedded at the logistics layer: the unique lot code printed on each blister links directly to HPLC potency data and LAL endotoxin results for that specific YK-11 batch, allowing end recipients to cross-reference quality documentation against the physical unit received. GMP-aligned handling procedures govern the warehouse-to-dispatch workflow, ensuring that the analytical standards applied during production are not undermined by inadequate storage or fulfillment conditions.

Product details

BrandVital Research
Active ingredientmyostine
Also known asmyostine, Myostine, Vital Research myostine
Strength5 mg
FormTabletten
Pack size30 pieces
Item numberSARM-MYOS-VIT-001

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