contraindications: Absolute contraindication with all nitrate-containing medications (glyceryl trinitrate, isosorbide mononitrate/dinitrate) and nitric oxide donors — co-administration causes uncontrolled, potentially fatal systemic hypotension.
Contraindicated in men with a recent (within 6 months) myocardial infarction, stroke, or unstable angina pectoris.
Avoid in severe hepatic impairment (Child-Pugh C); sildenafil clearance is critically reduced, leading to disproportionate plasma accumulation.
Not indicated for women, persons under 18, or anyone currently taking riociguat or other PDE5 inhibitors concurrently.
Alpha-blocker co-administration requires extreme caution; haemodynamic interaction can cause symptomatic orthostatic hypotension — allow minimum 4-hour separation when alpha-blockers cannot be avoided.
side_effects: Most frequently reported: headache, facial warmth, nasal congestion, and transient visual disturbance (blue-tint perception / blurred vision) — all mechanistically linked to off-target PDE6 inhibition or generalised vasodilation.
Priapism (erection lasting >4 hours) is a urological emergency; seek immediate medical care to prevent permanent cavernous tissue damage.
Hearing loss or sudden tinnitus has been reported in rare post-marketing cases; discontinue immediately and consult an ENT specialist.
Gastrointestinal effects (dyspepsia, nausea) occur in approximately 5–10 % of users according to post-registration surveillance data.
monitoring: Men with identified organic ED causes (diabetes, hypertension, dyslipidaemia) should have those underlying conditions actively managed — sildenafil treats the symptom, not the systemic disease.
Blood pressure should be measured before initiating sildenafil in any man with a history of cardiovascular disease; resting SBP below 90 mmHg is a contraindication.
IIEF questionnaire reassessment after 4–6 weeks of on-demand use helps objectively gauge whether the 50 mg or 100 mg dose achieves sufficient domain score improvement.
pct: Sildenafil is not a hormonal compound and does not suppress the hypothalamic-pituitary-gonadal axis; no post-cycle therapy protocol is required after sildenafil use.
If Cenforce 100 is used alongside anabolic steroids (a practice common in the bodybuilding context), note that some AAS agents cause endothelial dysfunction and dyslipidaemia, which can worsen underlying organic ED — address the root cause during PCT rather than relying solely on PDE5 inhibition.