Glutathione is an endogenous tripeptide composed of the amino acids glutamic acid, cysteine, and glycine, synthesized in virtually every human cell, where it serves as the central intracellular antioxidant — available here as a lyophilized powder for controlled reconstitution and parenteral or experimental use.
Pharmacological Mechanism
Glutathione acts primarily through the reactive thiol (-SH) group on its cysteine residue, which directly neutralizes free radicals and reactive oxygen species (ROS). In the course of this reaction, glutathione is converted to its oxidized disulfide form (GSSG), which is subsequently regenerated by the enzyme glutathione reductase at the expense of NADPH. Additionally, glutathione is an essential cofactor for glutathione peroxidase, which degrades lipid peroxides and hydrogen peroxide, and it participates in hepatic Phase II detoxification reactions, where glutathione S-transferases conjugate electrophilic xenobiotics to facilitate their renal elimination.
Research Context and Intracellular Significance
Intracellular glutathione levels are recognized as a biomarker for oxidative stress and mitochondrial health. In basic research, glutathione is extensively studied in the context of neurodegenerative diseases, immune modulation, chemotherapy-associated toxicity, and aging processes. Particular attention has been directed toward the role of the glutathione system in regulating T-cell proliferation and NK-cell activity. Because orally administered glutathione undergoes rapid hepatic hydrolysis, parenteral and alternative routes of administration are receiving increasing research interest due to their superior systemic bioavailability.
Lyophilized Form — Key Characteristics
Lyophilization — freeze-drying under vacuum — preserves the chemical integrity of reduced glutathione (GSH) over extended periods without the need for stabilizers or preservatives. The resulting powder is hygroscopic and is reconstituted with an appropriate solvent immediately prior to use. Compared to liquid formulations, this format offers distinct advantages in terms of storage stability, dosing precision, and transport logistics, making it particularly well-suited for preclinical and advanced experimental protocols.
Product Range & Selection
Glutathione | 600 mg/Vial | 1 Vial — lyophilized reduced glutathione (GSH) of pharmaceutical-grade purity, filled under protective atmosphere, intended for reconstitution with sterile water or physiological saline.
Lab Tested